Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates
نویسندگان
چکیده
منابع مشابه
State-dependent, bidirectional modulation of neural network activity by endocannabinoids.
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Over the past fifteen years, focused ultrasound coupled with intravenously administered microbubbles (FUS) has been proven an effective, non-invasive technique to open the blood-brain barrier (BBB) in vivo. Here we show that FUS can safely and effectively open the BBB at the basal ganglia and thalamus in alert non-human primates (NHP) while they perform a behavioral task. The BBB was successful...
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BACKGROUND Transcranial magnetic stimulation (TMS) has the potential to treat brain disorders by tonically modulating firing patterns in disease-specific neural circuits. The selection of treatment parameters for clinical repetitive transcranial magnetic stimulation (rTMS) trials has not been rule based, likely contributing to the variability of observed outcomes. OBJECTIVE To utilize our new...
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PURPOSE Focused Ultrasound (FUS) in conjunction with systemically administered microbubbles has been shown to open the Blood-Brain Barrier (BBB) locally, non-invasively and reversibly in rodents and non-human primates (NHP), suggesting the immense potential of this technique. The objective of this study entailed the investigation of the physiologic changes in the brain following the FUS-induced...
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ژورنال
عنوان ژورنال: Brain Stimulation
سال: 2021
ISSN: 1935-861X
DOI: 10.1016/j.brs.2021.01.006